Jorge Gonçalves: "Ketamine-assisted psychotherapy is an obvious route."

After The Clinic of Change's 1st Scientific Conference on Psychedelic-Assisted Psychotherapy, we heard from Jorge Gonçalves, Professor of Pharmacology at the Faculty of Pharmacy of the University of Porto.

Watch the video with the testimony.

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Jorge Gonçalves' statements on Ketamine-Assisted Psychotherapy:

I've been talking to my students about this treatment for years. And so, based on the scientific literature and the knowledge we have of pathophysiology, it's an obvious way forward and there is information about it.

I'm very pleased when I see people starting to line up to take basic knowledge, basic scientific, mechanistic knowledge, and translate it for patients. I'm very optimistic.

We know the mechanism of action of this drug quite well, we can anticipate the best conditions in which it can be used safely and effectively. We even have some indications of where we should look, which are the most likely sites, the most likely effects in terms of safety, in terms of toxicity. And even in terms of patients who might not respond so well.

This is an example of a drug that has all the conditions to be used in clinical practice, with another indication and taking advantage of its potential.

Conclusions of the conference on Psychotherapy with Psychedelics

These debates are fundamental and it's very sad that they no longer take place. Bringing different perspectives into the same space, a clinical perspective and a pre-clinical, mechanistic perspective. So, people who study what happens in cells, and then people who know what happens in patients. To make this translation.

It's not possible to make sound clinical decisions on the basis of clinical evidence alone, because clinical evidence can be misleading. We can have clinical evidence based on indicators that don't reflect the disease. If we are able to get these two communities working, the clinical and the pre-clinical, this is a particle accelerator.

I'm very optimistic about this experience and I hope it's a good practice, that it's an example for other cases.

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